True Crime is an open world action-adventure game played from a third-person perspective, in which the player controls Detective Marcus Reed of the PDNY. There are four "major cases" in the game; the Magdalena Cartel, the Palermo Mob, the Presidents Club, and the Shadow Tong. When the game begins, only the Magdalena Cartel case is available for play, but once that case has been closed, the player is free to play the remaining three cases in any order they wish.
The game falls into the subgenre of Grand Theft Auto clones as the core gameplay and game mechanics are very similar to 2001's Grand Theft Auto III, 2002's Grand Theft Auto: Vice City, and 2004's Grand Theft Auto: San Andreas. The player can travel across the city freely, commandeer vehicles, do whatever they want in terms of attacking and/or killing innocent civilians, progress through the storyline at their own leisure, spending as much time traversing the city as they wish, and engage in minigames and sidequests. The three main sidequests are a street racing circuit, an underground fight club tournament, and securing confidential informants.
A major difference from previous open world action-adventure video games, including the game's predecessor, True Crime: Streets of LA, is that many buildings throughout the city, beyond those related to the game's story, are accessible to the player. These include pharmacies, where the player can purchase medicine, and delis, where they can purchase food (both of which restore lost health), clothing stores where they can purchase new outfits, car dealers where they can purchase new cars, dojos where they can purchase new fighting techniques, record stores where they can purchase new songs for the game's soundtrack, gun stores where they can purchase new weaponry and ammunition, and other random buildings such as hotels, nightclubs, restaurants, and apartment buildings. Players can also purchase food from hot dog stands. In most business interiors, players can extort the owner for extra cash and/or plant evidence to make an arrest.
Another new addition to the True Crime franchise is the ability for the player to traverse the city not just on foot or by car, but by using public transport. The New York City subway system is available for use, and the player can also hail yellow taxis at any time, requesting transport to any point on the map. Both modes of transportation require a minimal fee.
The main game involves three main types of mission, each with its own unique gameplay; shooting, fighting and driving.
During shooting missions, the game auto-targets the closest opponent. If the player wishes to switch target to another opponent, they must do so manually. When the player is in shooting mode, they can enter "Precision Targeting" at any time. At this point, the game switches to first-person, zooms in on the target, and goes into slow motion momentarily. While in Precision Targeting, if the targeting reticule turns blue, the player can hit the enemy with a neutralizing, non-lethal shot. If the player fires when the reticule is red, the enemy will be killed instantly. Players can also take cover during shootouts, firing from behind cover when the opportunity presents itself. Players are also free to pick up any weapons dropped by enemies. Once the ammo of these weapons is depleted, however, Reed will drop the weapon and revert to his standard issue .38 ACP handgun, which, although it does need to be reloaded, never runs out of ammo.
In hand-to-hand combat, the player has three main attacks; light attack, heavy attack, and grapple. When the player grapples an opponent, they are free to throw them, or hit them with a number of light and/or heavy attacks. At certain points during combat, the enemy will be stunned, and a meter will appear on-screen prompting the player to press either the heavy attack or light attack button as much as possible within a set time. The more times the player presses the button, the more devastating the resulting special attack. The player can also toggle between different fighting styles, and switch to using a melee weapon at any time.
Driving missions can involve either trying to catch another car, or escape from another car. At all times, when the player is in a car, their car's condition is shown on screen. If the car's health meter empties, the car is close to destruction. As with Streets of LA, during normal driving missions, the player can solve random crimes given by the radio dispatcher, although, unlike in the first game, these crimes can now take place inside buildings as well as on the streets. Additionally, the map is divided up into twenty different neighborhoods. When Reed solves a random crime in a particular area, the crime rate in that area drops. After he has solved a set number of crimes in one area, that area is considered "clean," and crime rates will not increase (although random crimes will still occur within the area). If Reed continues to ignore random crimes in a given area before it is clean, the crime rate in that area will increase, leading to stores closing, dirtier streets, boarded up buildings, more aggressive civilians, and resulting in more random crimes needed to clean the area up.