After spending a night in the woods outside Oregon, the brothers are recognized by the owner of a roadside convenience store, who knocks out and kidnaps Sean. Daniel frees Sean as they escape with the help of travel blogger Brody Holloway. During the escape, Daniel steals a puppy from the store and names her Mushroom. Brody leaves them at a motel a few miles from Arcadia Bay with supplies for the rest of their journey. Daniel learns of their father's death on the news and has a meltdown that almost destroys the motel, revealing he has latent telekinesis and was inadvertently responsible for the earlier explosion. As the brothers continue south, Sean teaches Daniel to control his new powers. Daniel falls ill, forcing Sean to change course to their grandparents' house in Beaver Creek, Oregon, just as Mushroom is killed by a cougar. The brothers reunite with their maternal grandparents, Claire and Stephen Reynolds, but when Daniel shows interest in learning about his mother Karen (who abandoned her family shortly after Daniel's birth), Claire rebuffs them and keeps Karen's room locked.
Daniel later witnesses the Reynolds' neighbor Chris Eriksen falling from his treehouse and uses his power to save him. Chris, an avid superhero fan, believes he is the one with powers. Later that day, Sean and Daniel discover a recent letter from Karen expressing the desire to meet her children, leading to an argument with Claire and Stephen. The police arrive in search of Sean and Daniel, and Claire distracts them so the brothers can escape via the Eriksens' backyard. Chris either helps them escape unnoticed, discovers that Daniel is the one with powers, or is hit by a pursuing police car. Sean and Daniel stow away on a train to California, where they reunite with Finn and Cassidy, two freighthoppers they previously encountered at a Beaver Creek Christmas market. Sean and Daniel earn money working at a marijuana farm in Humboldt County for a cultivator named Merrill. Sean spends his time with Cassidy and her friends, neglecting a frustrated Daniel as his powers continue to grow.
As the group is about to be paid, Daniel is caught sneaking into Merrill's office, causing an angry Merrill to refuse payment for the others and fire Sean and Daniel. Daniel accidentally exposes his powers to the others while defending himself from Merrill's henchman. While the others promise to keep it a secret, Finn suggests using Daniel to steal from Merrill. Regardless of whether Sean approves or not, the heist goes ahead. Daniel and Finn accidentally alert Merrill, who holds Sean, Daniel, Finn, and potentially Cassidy at gun-point. In the ensuing confrontation, Daniel violently loses control of his powers and destroy Merrill's house. By the following morning, Daniel has disappeared with Merrill's money, leaving the others - including Sean, unconscious and half-blinded by a shard of glass embedded in his left eye - behind.
Two months later, Sean wakes up from a coma in a hospital in Northern California, where he is kept for questioning by the FBI as they search for the still-missing Daniel. Sean discovers a note left in his journal by Jacob, a contact from the marijuana farm, revealing that in the aftermath of the explosion, Jacob escorted Daniel to his former home of Haven Point, Nevada. Sean escapes from custody, hotwires a hospital employee's car, and begins the journey to Nevada. After stopping for the night, Sean is assaulted and humiliated by two racist locals, before running out of gas. Sean begins to walk the rest of the way until he is offered a lift by a friendly trucker.
Arriving in Haven Point, a commune for the cult-like Universal Uprising Church led by the charismatic Reverend Mother Lisbeth, Sean is horrified to discover Daniel being called the "Angel Daniel", with his powers being preached as a divine gift by Lisbeth to her congregation. Sean attempts to take Daniel away, but Lisbeth has manipulated him and he refuses to leave. Church altar boy Nicholas forces Sean to leave at gunpoint. Sean is stunned to find Karen waiting outside, who had traveled to Nevada after receiving a letter from Jacob, although Sean still holds a grudge and is reluctant to trust and forgive her after she abandoned him and his brother many years ago.
Sean and Karen formulate plans to rescue Daniel from the church. The next day, Sean meets with Jacob, who wants to retrieve his ill sister, Sarah-Lee, from Lisbeth's clutches. Sean and Jacob break into Lisbeth's home while Karen keeps watch, where Sean learns that Lisbeth was excommunicated from her previous church for her extreme beliefs, forced Jacob to undergo gay conversion therapy, and has been preventing Sarah-Lee from receiving medical help despite a diagnosis of severe pneumonia. As Jacob escapes with Sarah-Lee, Sean and Karen storm the church to retrieve Daniel, and Nicholas attacks Sean on Lisbeth's orders. Sean makes a heartfelt plea to Daniel, helping Daniel come to his senses and break free of Lisbeth's control and save Sean. The fight accidentally starts a fire on the altar, and Sean, Daniel, and Karen flee the church as it burns to the ground. The reunited family finally make their way toward the Mexican border.
