The zombies in the game are able to attack the player in a multitude of ways. A zombie mutant that gets too close to the player will usually attempt to grapple the player, prompting the player to rapidly shake his or her analogue stick to avoid getting bitten. Players who are unsuccessful in doing this will be infected for a limited amount of time. Whilst they are infected they gain small bonuses at the expense of a slowly depleting health bar. If a player is successfully bitten and later runs out of time after becoming infected, the player will lose control of his character and begin attacking his former teammates until killed, allowing the player to respawn. There are additional enemy types in the game besides zombies, such as Lickers, Hunters, and Cerberuses. Furthermore, the players are able to control them under certain circumstances.
Heroes Mode is an online multiplayer feature allowing to play characters such as Leon S. Kennedy (Christian Lanz), Claire Redfield (Alyson Court), Jill Valentine (Michelle Ruff) and Carlos Oliviera (Gideon Emery), plus Ada Wong (Courtenay Taylor), HUNK (Keith Silverstein), Nicholai Ginovaef (Rick D. Wasserman), and a new character, Lone Wolf (Jon Curry). Xbox 360-exclusive Nemesis Mode allows one player to control Nemesis and use him to kill the other team.
Plot
USS
Umbrella Security Service (USS) Delta team enters the Raccoon City Underground Laboratory, where they meet up with Alpha team leader HUNK. Their mission is to assist Alpha team in stopping Dr. William Birkin from handing over his T-virus research to the U.S. military and retrieve the G-virus. On their way to Birkin's lab, they find Birkin has paid numerous Umbrella Biohazard Countermeasure Service (UBCS) mercenaries to work for him while the deal goes forward. When they reach Birkin's lab, the doctor is shot, and HUNK and another Alpha leave with the samples. They soon find that Birkin survived the attack and infected himself with the virus. The Birkin creature proceeds to kill off most of Alpha team before disappearing; HUNK offers to go back in search of the sample.
Not long after the battle, it becomes evident that the T-virus has leaked citywide, and people are beginning to transform into flesh-hungry zombies. In what they see as a punishment by USS command, Delta team is ordered to remove evidence of Umbrella's role in the outbreak. Heading into Raccoon City Hall, Delta team meets with a UBCS mercenary and their monitor Nicholai Ginovaef; he is soon revealed as a traitor and attempts to kill Delta team.
Later, the team is sent out around Raccoon Park to find the Nemesis-T Type, which has gone rogue. A second parasite is injected into its body in order to bring it back under control. Shortly after this mission is completed, the team is then sent out to the Raccoon City Police Department, ordered to kill any surviving police officers and destroy evidence linking the company to the outbreak. When this is done, the team exits the station, and soon after encounter Leon S. Kennedy, whom they begin to hunt down along with Sherry Birkin. After they find and corner Leon, Claire Redfield and Sherry, the game can end in two ways: in one ending, the surviving members of the team resign from Umbrella over their abandonment during the mission and betray them by letting the three live; in the other, Leon and Claire are executed and Sherry is sent to an Umbrella facility.
Echo Six
Spec Ops Command deployed Echo Six team into Raccoon City in order to discover the causes of the outbreak. Heading into Raccoon City Police Department, they meet with Jill Valentine, who is fleeing the Nemesis. She points Umbrella as the responsible for the outbreak and advises the team to investigate the City Hall for evidence before parting. There Echo Six finds blueprints of an Umbrella underground laboratory and heads to the sewers to find its entrance, fighting Nemesis along the way.
Moving further into the sewers, Echo Six comes into contact with the mutated Birkin attacking USS soldiers, and Claire Redfield, who is searching for Sherry Birkin. The team escort Claire and find Sherry, before being ambushed by Birkin. Claire takes Sherry away through a doorway as Echo Six covers their escape; they then defeat Birkin and continue their mission.
Finding the underground lab, Echo Six learns that T-Virus is the cause of the outbreak and that the G-Virus could make the situation worse. They are given orders to collect a sample of the G-Virus for further study. Further into the lab, they learn that Sherry is carrying a G-Virus sample and a Tyrant is being programmed to hunt her down to retrieve it. Destroying the terminals to prevent the Tyrant's programming complete, the creature awakens anyway and attacks the team. They activate the lab self-destruct system to kill it and flee to the surface; the Tyrant is set upon by Nemesis parasites and becomes the Parasite Super Tyrant.
Spec Ops Command receives a distress call from Leon S.Kennedy, informing them of the whereabouts of Claire and Sherry; Echo Six is tasked with assisting in their evacuation. In the extraction zone, they are attacked by the Parasite Super Tyrant; Echo Six fights it and kills it. Leon, Claire and Sherry are then evacuated on the chopper as Command tells Echo Six to stay behind for one last mission that only they can accomplish.
