Resident Evil 5 is a third-person shooter with an over-the-shoulder perspective. Players can use several weapons including handguns, shotguns, automatic rifles, sniper rifles, and grenade launchers, as well as melee attacks. Players can make quick 180-degree turns to evade enemies. The game involves boss battles, many of which contain quick time events.
As in its predecessor Resident Evil 4, players can upgrade weapons with money and treasure collected in-game and heal themselves with herbs, but cannot run and shoot at the same time. New features include infected enemies with guns and grenades, the ability to upgrade weapons at any time from the inventory screen without having to find a merchant, and the equipping of weapons and items in real-time during gameplay. Each player can store nine items. Unlike the previous games, the item size is irrelevant; a herb or a grenade launcher each occupy one space, and four items may be assigned to the D-pad. The game also features fewer puzzles than previous titles.
Resident Evil 5 is the first game in the Resident Evil series designed for two-player cooperative gameplay. The first player controls Chris, a former member of the fictional Special Tactics and Rescue Service (STARS) and current member of the BSAA, and a second player can control Sheva, who is introduced in this game. If a person plays alone, Sheva is controlled by the game's artificial intelligence (AI). When the game has been completed once, there is an option to make Sheva the primary character. Two-player mode is available online or split-screen with a second player using the same console. A second player joining a split-screen game in progress will make the game reload the last checkpoint (the point at which the game was last saved); the second player joining an online game will have to wait until the first player reaches the next checkpoint, or restarts the previous one, to play. In split-screen mode, one player's viewpoint is presented in the top half of the screen, and the other in the bottom half, but each viewpoint is presented in widescreen format, rather than using the full width of the screen, resulting in unused space to the left and right of the two windows. If one player has critical health, only their partner can resuscitate them, and they will die if their partner cannot reach them. At certain points, players are deliberately separated. Players can trade items during gameplay, although weapons cannot be traded with online players. The game's story-line is linear, and interaction with other characters is mostly limited to cut-scenes.
A version of the Mercenaries minigame which debuted in Resident Evil 3: Nemesis is included in Resident Evil 5. This minigame places the player in an enclosed environment with a time limit. Customized weapons cannot be used and players must search for weapons, ammunition, and time bonuses while fighting a barrage of enemies, to score as many points as possible within the time limit. The minigame multiplayer mode was initially offline only; a release-day patch needed to be downloaded to access the online multiplayer modes. Mercenaries is unlocked when the game's story mode has been completed.
Plot
In 2009, five after the events of Resident Evil 4, Chris Redfield, is a member of the fictional Bioterrorism Security Assessment Alliance, is dispatched to Kijuju in Africa. He and his new partner Sheva Alomar are tasked with apprehending Ricardo Irving before he can sell a bio-organic weapon (BOW) on the black market. When they arrive, they discover that the locals have been infected by the parasites Las Plagas (those infected are called "Majini") and the BSAA Alpha Team have been killed. Chris and Sheva are rescued by BSAA's Delta Team, which includes Sheva's mentor Josh Stone. In Stone's data Chris sees a photograph of Jill Valentine, his old partner, who has been presumed dead after a confrontation with Albert Wesker. Chris, Sheva and Delta Team close in on Irving, but he escapes with the aid of a hooded figure. Irving leaves documents that lead Chris and Sheva to marshy oilfields. This is where Irving's deal is to occur, but they discover that the documents are a diversion. When Chris and Sheva try to regroup with Delta Team, they find the team slaughtered by a BOW; Sheva cannot find Stone among the dead. Determined to learn if Valentine is still alive, Chris does not report to headquarters.
Continuing through the marsh, they find Stone injured but safe and track down Irving's boat with his help. Irving injects himself with a variant of the Las Plagas parasite and mutates into a huge octopus-like beast. Chris and Sheva defeat him, and his dying words lead them to a nearby cave to learn more. The cave is the source of a flower used to create viruses previously used by the Umbrella Corporation, as well as a new strain named Uroboros. Chris and Sheva find evidence that Tricell, the company funding the BSAA, took over a former Umbrella underground laboratory and continued Umbrella's research. In the facility, they discover thousands of capsules holding human test subjects. Although Chris finds that one of the capsules is Valentine's, it is empty. When they leave, they discover that Tricell CEO Excella Gionne has been plotting with Wesker to launch missiles with the Uroboros virus across the globe; it is eventually revealed that Wesker hopes to take a chosen few from the chaos of infection and rule them, creating a new breed of humanity. Chris and Sheva pursue Gionne but are stopped by Wesker and the hooded figure, who is revealed to be a mind-controlled Valentine. Gionne and Wesker escape to a Tricell oil tanker; Chris and Sheva fight Valentine, subduing her and removing the mind-control device before she orders Chris to follow Wesker.