Plot
The entire game is a "What If?" scenario where Frank West covered the Fortune City outbreak, instead of Chuck Greene. As such, the game isn't considered canon within the Dead Rising continuity. It also changes the plot of Dead Rising 2 significantly in regards to the different characters and their motives.
After surviving the zombie outbreak that occurred in Willamette (though now infected), freelance photojournalist Frank West quickly became a celebrity for exposing the truth behind the outbreak. However, his heroic fame soon vanished due to frequent scandals and controversies. In hopes to regain a place in the spotlight, he accepts an offer from Tyrone "TK" King to appear as a special guest on the controversial pay-per-view zombie-killing show Terror is Reality, taking place in Fortune City, Nevada.
At the beginning of the event, Frank wears a wrestling outfit and is lifted via platform into a wrestling ring and made to kill zombies. After the event is finished, a humiliated Frank takes his winnings and leaves. As he is leaving, he overhears TK talking with someone and goes to investigate. With his camera, Frank manages to take some pictures of TK handing money and a strange item to a young man, though a few of TK's thugs attack him when he tries to escape. Frank then calls the elevator to leave, but a loud tremor knocks him out. When Frank wakes up, he finds that the zombies have gotten loose and are now infesting Fortune City, where he fights through the undead hordes to the emergency shelter. Security chief Raymond Sullivan initially refuses Frank due to his infection, but Frank bluffs his way in with an empty box of the anti-zombification drug Zombrex. He then meets Stacey Forsythe, who leads her branch of the protest group CURE (Citizens for Undead Rights and Equality) and had been in Fortune City to protest Terror is Reality's zombie-exploitation when the outbreak began. After helping Frank find a dose of Zombrex, Stacey monitors Fortune City from the Safe House and informs him of any new developments or signs of survivors. In three days, the military will arrive to rescue them all.
A news report appears on the Safe House television, and reporter Rebecca Chang runs footage of TK's accomplice placing a bomb on the zombie holding pens. Stacey recognizes him as Brandon Whittaker, a member of CURE, and her group is blamed for starting the outbreak. Frank goes out to meet Rebecca and the two of them search a security room in the Arena, which has been sabotaged and destroyed. Back in the Safe House, Stacey spots Brandon hiding in a bathroom in Uranus Zone and Frank goes to confront him about his involvement in the outbreak; he finds that Brandon has gone violently insane and is killed by Frank during the fight between them. Frank confronts Stacey about how Brandon was part of CURE and how he started the outbreak, and she responds that he was new and TK must have planted him in the group. They continue to argue until Frank notices people moving equipment in the underground on a security camera. Moving through the underground tunnels and fighting off guards, Frank confronts TK and the game-show host admits that he is indeed behind the outbreak before escaping. TK's men then begin robbing Fortune City's casinos, though Frank stops the attempted heist.
Rebecca invites Frank to come with her and meet her source. Frank arrives, but finds nothing except a transceiver. TK talks to Frank on the other line, demanding that he bring $1,000,000 to the Shoal Nightclub or Rebecca dies. Frank arrives with the money and is confronted by her "source" Amber and Crystal, TK's twin girlfriends and bodyguards. He manages to kill one of them, and the latter commits suicide out of grief. Rebecca and Frank chase TK to the roof of the hotel, where he is preparing to escape Fortune City on helicopter. Frank foils the escape and captures TK, who is held prisoner at the Safe House.
By this time, the military has arrived in Fortune City to begin the cleanup and rescue. At first, the soldiers have little trouble with the zombies, but soon a green gas begins rising from the vents in the ground; this causes some of the zombies to mutate into gas zombies, becoming faster, stronger, and seemingly unkillable. Due to this, the military team is nearly wiped out. Sergeant Dwight Boykin, in charge of the team, escapes the zombies and Rebecca follows. Frank heads to the underground, and finds that Sergeant Boykin has gone completely insane and is holding Rebecca hostage. After defeating the sergeant, Frank gets Rebecca back to the Safe House. TK refuses to say anything about the gas. When asked why he framed CURE, he says that Brandon was just the name "they" gave him. The Safe House doors are suddenly breached, allowing zombies to flood inside. Frank manages to hotwire the inner doors to close, but he realizes that the breach wasn't an accident, Nearby, TK tries to escape but is knocked over by a zombie and bitten. Enjoying the irony but needing him alive for his story, Frank contemplates on whether he should give TK a dose of Zombrex. He ultimately does so despite TK's ungrateful insults.
